in Mailand (Italien)

Prof. Alessandro Castagna is the Orthopedic Surgery of the Shoulder and Elbow Unit Director in Humanitas Research Hospital. He performs both traditional surgeries and arthroscopic surgeries. He developed experience in arthroscopic surgery of the shoulder in the United States where he studied at the Southern California Orthopedic Institute, under the guidance of Dr. Stephen J. Snyder (famous shoulder surgeon, inventor and co-developer of surgical tools for shoulder arthroscopy).

Prof. Castagna gained experience in open surgery of the shoulder under the guidance of Prof. Mario Randelli, founder and past-president of the Italian Society for Surgery of the Shoulder, in Milan (Italy). He has specialized almost exclusively in shoulder surgery for more than 25 years and counts over 40.000 cases in his career. He carries out about 900 surgeries per year, including total shoulder prostheses, reverse prostheses, open and arthroscopic stabilization, rotator cuff repair and proximal humerus fractures.

Research areas of interest: 

Improvement of surgical and therapeutic methods of shoulder pathology. He gives particular attention to the study of biological and functional aspects with the development of surgical techniques, materials and dedicated tools. 

Teaching experience: Adjunct Professor at the Orthopedics Course of Specialization in Diseases of the Locomotor System at the University of L'Aquila.

Scientific activity: 

Prof. Castagna was president of European Society for Surgery of the Shoulder and the Elbow (ESSSE/SECEC) (www.secec.org) from 2012 to 2014 and president of Italian Society for Surgery of the Shoulder and Elbow (SICS&G) (www.sicseg.it) from 2010 to 2012. He is also a Member of the Board di International Congress of Shoulder and Elbow Surgery (ICSES, www.icses.org) nominated for the period from 2013 to 2022.

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=castagna+alessandro

Prof. Alessio Michele Goffredo Aghemo is the Hepatology Unit Director in Humanitas research Hospital.

Medical areas of interest: 

• liver diseases
• viral hepatitis
• metabolic hepatitis
• liver cirrhosis

Previous experience: 

From 2007 to 2017 he was the 1st level Medical Director at the U.O of Gastroenterology of the IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan.

Research areas of interest: 

Clinical and research activity focused on natural history and treatment of viral hepatitis.

He is the author of 155 peer-reviewed publications (Impact Factor total 1151.3, H-Index 25 according to Scopus, H-Index 20 last 5 years Scopus, H-Index 30 according to Google Scholar) (updated September 2017).

From 2013 to 2016 he was a scientific member of the governing board of the European Association for the Study of the Liver (EASL).

Since 2016 he is a member of the scientific committee of the European Association of Gastroenterology (UEG).

He is a member of the AISF (Italian Association for the Study of the Liver) commission for antiviral drugs directed against HCV (2012-present). Since 2016 he has been the coordinator of the same. 

He was AIFA/EMEA expert for liver disease since 2008.

Member of the Executive Committee of the HCV Regional Network, determined by the Lombardy Region on 28 September 2015.

He participated as an expert in the drafting of the European Guidelines 2013-2014-2015-2016-2017 (EASL) and Italian (AISF) on the Treatment of Chronic Hepatitis C.

Teaching experience:

He is associated professor of Gastroenterology at Humanitas University since September 2017.

Prof. Arturo Chiti graduated in Medicine and Surgery at the University of Milan in 1989, and in the same year he entered the Post graduated School in Nuclear Medicine at the University of Milan, where he got his degree in 1993. In the same year he started working as Associate Chief at the National Cancer Institute in Milan, where he began his clinic and scientific experience in Oncology.
In 1997, he got the European Board of Nuclear Medicine fellowship.

In June 2000 he started leading the Nuclear Medicine Department at Humanitas Research Hospital.

On March 1, 2015 he was appointed Full Professor in Diagnostic Imaging and Radiotherapy at the Humanitas University in Milan, where he is also elected member of the Board.

Prof. Chiti is the Unit Director of the Nuclear Medicine Unit in Humanitas Research Hospital. He is the Director of the Post Graduate School in Diagnostic Imaging at Humanitas University. He is member of the Technical and Scientific Committee of the National Centre for Oncologic Adrotherapy (CNAO).

Arturo Chiti is co-author of several papers (www.scopus.com, www.pubmed.com) with an H-index of 30 (July 2016), wrote some books’ chapters and contributed to many abstracts presented at international and national meetings.
He is Honorary Editor of the European Journal of Nuclear Medicine and Molecular Imaging and reviewer for several international journals and grant applications.

He is a well-known invited speaker at numerous international congresses and conferences.

Prof. Arturo Chiti is the President of the European Association of Nuclear Medicine (EANM), where he has been active for more than 10 years.

He is also acting as an expert consultant for International Atomic Energy Agency (IAEA) and is member of the International Commission on Radiation Units and Measurements (ICRU).

He was awarded the honorary membership of the European Society for Therapeutic Radiology and Oncology (ESTRO); the Tom Miller Memorial Lecture Award from the Society of Nuclear Medicine and Molecular Imaging and the Hevesy Gyorgy award from the Hungarian Society of Nuclear Medicine.

Publications:

https://www.ncbi.nlm.nih.gov/pubmed/?term=chiti+arturo

Prof. Bruno Bernardini is the Neurological Rehabilitation Unit Director in Humanitas Research Hospital. 

Medical areas of interest:

Rehabilitation in acute-subacute phase of disabled patients for neurological diseases (stroke, cranial-encephalic and medullary trauma, tumors of the nervous system, neuropathies). Hospital risk of fragile elderly patients. Orthogeriatrics.

Research areas of interest:
Post-operative rehabilitation indicators and process-outcome measures for patient prognostic stratification and clinical performance evaluation. 

He is the coordinator of a multicentre study for the application of process-outcome indicators in rehabilitation. The study involves hospital and extra-hospital facilities in Lombardy, Liguria and other regions of Central and Northern Italy.

Previous experience:

2005-2007 Galliera Hospital Authority, Genoa, Italy

Director of the Functional Recovery structure.

Member of the work group for defining the Regional Plan of rehabilitation work 2006-2009 in the Liguria region.

Evaluation, treatment and facilitation of care processes in patients in Neurology, Intensive Care, Neuro-surgery, Intermediate Care, Orthopaedic and Home Care. 

Outpatient work as a physiatric specialist, with a specific sector on the rehabilitation of the pelvic floor.

Development of processes in diagnostic and therapeutic hospital care (especially lumbar-sciatica, joint replacements, cardiac failure, femur fractures and most fast-track urological operations).

1988-1995 Hospital of Niguarda, Milan, Italy
Visiting doctor at the Centre for High Specialisation in Allergology and Clinical Immunology with full-time specialisation in the Department of Pneumology Piazza.

Teaching experience: Medicine Professor at the University of Genoa.

Scientific activities: Member of the board of directors and Geriatric area contact person at “Italian Urodynamic Society Continence, Neuro-Urology, Pelvic Floor”

Dott. Antonio Frontera is the Electrophysiology Unit Director in Humanitas Research Hospital.  

Medical areas of interest: 

After graduating in Medicine and Surgery at the University Cattolica del Sacro Cuore in Rome in 2006, he specialized in Cardiology at the same university in 2012.

Soon after his specialization he moved to England where he was hired as a Clinical and Research Fellow in cardiac electrophysiology at the Bristol Heart Institute (NHS), Bristol. 
He won a scholarship from the European Society of Aritmology (EHRA) and completed his training in cardiac electrophysiology at the prestigious Haut Léveque Hospital in Bordeaux, France, directed by Prof. Michel Haïssaguerre. In the same French university, he obtained his PhD.

During these 5 years of training abroad, he performed about 800 trans catheter ablation surgeries focusing mainly on the treatment of supraventricular arrhythmias. As a researcher, he has published nearly 100 scientific papers on innovation and trans catheter ablation techniques, defibrillator and pacemaker functioning algorithms.

Back to Italy, he was employed at the Aritmology Unit of the San Raffale Hospital specializing in the treatment of ventricular tachycardia, performing more than 150 procedures as a first and second operator.

To date, Dr. Frontera is the author of more than 145 scientific papers published in international journals. He constantly participates in national and international congresses of the sector.

Research areas of interest:
He has particular interest in the analysis of endocavitary signals (EGMs) in ventricular tachycardia and atrial fibrillation.

Thanks to a close collaboration with the Mathematics department of Politecnico di Milano, directed by Prof. Quarteroni, he studied innovative techniques for the treatment of complex arrhythmias.

Previous experience:
 

• Clinical and Research Fellow in Cardiac Electrophysiology - Bristol Heart Institute, Bristol, UK
• Clinical and Research Fellow in Cardiac Electrophysiology - Hôpital Haut Léveque, Bordeaux, FR

Publications: 

Sinus node exit, crista terminalis conduction, interatrial connection and wavefront collision: key features of human atrial activation in sinus rhythm.
Pambrun T, Derval N, Duchateau J, Ramirez FD, Chauvel R, Tixier R, Marchand H, Bouyer B, Welte N, André C, Nakashima T, Nakatani Y, Kamakura T, Takagi T, Krisai P, Ascione C, Balbo C, Cheniti G, Vlachos K, Bourier F, Takigawa M, Kitamura T, Frontera A, Meo M, Denis A, Sacher F, Hocini M, Jaïs P, Haïssaguerre M.Heart Rhythm. 2022 Jan 13

Electrogram fractionation during sinus rhythm occurs in normal voltage atrial tissue in patients with atrial fibrillation.
Frontera A, Limite LR, Pagani S, Cireddu M, Vlachos K, Martin C, Takigawa M, Kitamura T, Bourier F, Cheniti G, Pambrun T, Sacher F, Derval N, Hocini M, Quarteroni A, Della Bella P, Haissaguerre M, Jaïs P.Pacing Clin Electrophysiol. 2021

Slow Conduction Corridors and Pivot Sites Characterize the Electrical Remodeling in Atrial Fibrillation - ScienceDirect
Antonio Frontera MD, Ph.D1, Stefano Pagani Ph.D2, Luca Rosario Limite MD1, Andrea Peirone MD1, Francesco Fioravanti MD1, Bogdan Enache MD6, Jose Cuellar, MD4, Konstantinos Vlachos, MD5, Christian Meyer, MD, MA7, Giovanni Montesano, MD8, Andrea Manzoni, Ph.D2, Luca Dedè2 Ph.D2, Alfio Quarteroni, Ph.D2,3, Decebal Gabriel Lațcu, MD6, Pietro Rossi MD, Ph.D9, Paolo Della Bella MD1.
JACC EP Jan 2022

Right ventricular outflow tract electroanatomical abnormalities in asymptomatic and high-risk symptomatic patients with Brugada syndrome: Evidence for a new risk stratification tool?
Letsas KP, Vlachos K, Conte G, Efremidis M, Nakashima T, Duchateau J, Bazoukis G, Frontera A, Mililis P, Tse G, Cheniti G, Takigawa M, Pambrun T, Prappa E, Sacher F, Derval N, Sideris A, Auricchio A, Jais P, Haissaguerre M, Hocini M.J Cardiovasc Electrophysiol. 2021

Effect of electrode size and spacing on electrograms: Optimized electrode configuration for near-field electrogram characterization.
Takigawa M, Kitamura T, Basu S, Bartal M, Martin CA, Martin R, Cheniti G, Vlachos K, Pillois X, Frontera A, Massoullié G, Thompson N, Bourier F, Lam A, Duchateau J, Pambrun T, Denis A, Derval N, Cochet H, Haïssaguerre M, Sacher F, Hocini M, Jaïs P.Heart Rhythm. 2022 Jan;

Prof. Salvatore Badalamenti is the Nephrology and Dialysis Unit Director in Humanitas Research Hospital. He has graduated at the Università degli Studi of Milan and is specialised in Medical Nephrology, Liver Diseases and Replacement.

Medical areas of interest:

• clinical nephrology and dialysis, chronic renal failure and its complications (anemia, osteodystrophy)
• preparation of vascular access for hemodialysis
• acid-base balance disorders. continuous renal replacement therapy in intensive care (CRRT)
• hepatorenal syndrome
• emergency medicine

Previous experience:

1990-1995 Polyclinic Hospital, Milan, Italy
He was a Staff grade specialist. Focused on infectious complications in dialysis treatments, particularly hepatitis C and anaemia, and nephrological and dialysis emergencies.

1986-1990 Provincial Hospital Clinic , Barcelona, Spain
He completed his PhD in Renal and Hepatic pathophysiology. Especially focused on the study of renal complications in patients with liver disease.

Research areas of interest: 

• clinical nephrology
• anemia and erythropoietin in renal failure and dialysis
• continuous renal replacement therapy in intensive care (crrt)
• hepatorenal syndrome. 
• phgosis and pentraxine in renal failure

He is a member of the Board of Directors of the Italian Society of Nephrology (SIN)

Teaching experience:

He is Professor of Internal Medicine and Emergency medicine and Professor of Nephrology at Università degli Studi of Milan.

Dr. Paolo Casale is the Urology Unit Director in Humanitas Research Hospital. 

Medical areas of interest: 
his main focus is surgical treatment of oncological and functional diseases of the kidney, bladder and prostate.

He has developed a particular interest in conservative oncological surgery of the kidneys, both traditional and minimally invasive (laparoscopic and robotic), and has dedicated himself to the study of prostate and bladder oncological pathologies, with particular attention to the different urinary derivations, such as orthotopic neobladders.

Research areas of interest:
Surgical techniques in the treatment of kidney, bladder and prostate cancer.

Previous experience:

• 1999 – 2014 University Hospital of Pisa – Pisa (PI), Italy
  Medical Director at the Urology Unit 2 (Reference Center for Kidney tumors) headed by Dr. Francesco Francesca. Here he served as the organization and surgical training manager in the operating room of Residents in Urology and Students of Degree in Medicine and Surgery.
• He has also held the following positions: 
•  
• May 2012 – May 2013: Head of the Section of Professional interdisciplinary relevance of Robot-assisted Laparoscopic Surgery 
•  
• Nov 2008 – April 2012: Head of the Robot assisted Laparoscopic Surgery
•  
• 1994 – 2004: Research Fellow in Laparoscopic Surgery and Robotics at the Glickman Urological Institute at The Cleveland Clinic Foundation on advanced laparoscopic procedures, Robotic Surgery and Minimally Invasive Surgery – Cleveland – USA. (Chief: IS Gill).
•  
• December 1995 – May 1996: Research Fellow at the Department of Urology, Henry Ford Hospital – Detroit – Michigan – USA. (Chief: JO Peabody).
•  
• 1994: Clinical Internship at the Department of Urology, Montefiore Medical Center – Albert Einstein ​​University – New York – USA. (Chief: A. Mellman).

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=casale p 

Prof. Carlo Castroro is the General Gastric and Esophagus Surgery Unit Director in Humanitas Research Hospital. He has graduated in the University of Padua and specialised in general medicine and thoracic surgery.

Medical areas of interest:

• gastric esophagus surgery
• day surgery
• general surgery

Previous experience:

Head of Simple Departmental Oncological Surgery Unit at the “Istituto Oncologico Veneto”, IOV - IRCCS, Padua.

Research areas of interest: 

• gastro-intestinal oncological surgery
• diseases of the esophagus with particular focus on oncologicy
• training, new technologies and distance learning
• day surgery and surgical services reorganization

Teaching experience: He is a professor in the Graduate School of General Surgery of the University of Padua and has also participated as a lecturer in numerous postgraduate training courses in the field of esophageal surgery, day surgery and minimally invasive surgery.

Publications: https://www.ncbi.nlm.nih.gov/pubmed/?term=castoro+carlo

Prof. Efrem Civilini  is chairman at Humanitas University and Vascular Surgery Unit Director at Humanitas Research Hospital.

He received his medical degree from the University of Milan, Italy and board-certified in Vascular Surgery at the University of Siena, Italy. He took his internship and residency in vascular surgery at San Raffaele Scientific Institute, Milan (Italy) where he completed his training with clinical and research fellowships under the guidance of his mentor Prof. Roberto Chiesa.

As an attending surgeon and later as chief of Thoracic Aortic Surgery at the Cardiovascular Department of San Raffaele he practiced his surgical skills in an internationally recognized team treating thoraco-abdominal aneurysms and then studied minimally invasive aortic surgery at the Cleveland Clinic (OH). After an experience of about 15.000 vascular surgerie, in 2015 was appointed to Humanitas at the head of a relatively young team: the department of Vascular Surgery I. This department provides comprehensive treatments for all types of vascular disorders including the new technology of catheter-based intervention as well as traditional surgical treatment all geared toward maximizing safety and optimizing outcomes.

Prof. Civilini’s research has been focused on aortic surgery and minimally invasive vascular therapies. He co-authored practice guidelines for the treatment of patients with cardiovascular diseases and has played a role in industry-sponsored clinical trials assessing the performance of new expandable stents used to treat thoracic aorta disease. He has been invited to present his clinical experience at international and national medical conferences and symposia.

He has authored or co-authored several peer-reviewed articles and book chapters on his clinical experience and research. He serves as a reviewer for the Annals of Vascular Surgery and is member of the European Society of Vascular Surgery and the Società Italiana di Chirurgia Vascolare ed Endovascolare.

Previous experience:

1995-2014
Scientific Institute San Raffaele, Milan. Italy
Staff surgeon and Director of the Thoracic Aortic Surgery

2003-2014
“Vita – Salute” University, Milan. Italy
Fellow and Contract Professor of Surgery

2008 
Cleveland Clinic, Cleveland (OH)
Additional training in catheter-based interventions and endovascular surgery of thoraco-abdominal aneurysms.

Publications:

http://www.ncbi.nlm.nih.gov/pubmed/?term=Civilini%20E%5BAuthor%5D&cauthor=true&cauthor_uid=26344379

Dr. Paola Maria Magnoni has graduated in general medicine and radiodiagnostics at Università degli Studi of Milan and is the Ultrasound Unit Director of Humanitas Research Hospital, where she dedicates especial attention to internal, oncological, breast, endocrinology and loop ultrasound, performing over 5000 examinations of which 500 needle biopsy annually.

Medical areas of interest: Ultrasound in all its fields of use, especially:

Diagnostic ultrasound: internal, oncological, intestinal loops, endocrinology.

Interventional ultrasound: superficial needle biopsies of areas such as breast, thyroid, soft parts; and deep needle biopsies of areas such as abdominal organs, liver, kidney pancreas; retroperitoneum; paracentesis, thoracentesis, drainage and inflections.

Research areas of interest: sarcomas, early diagnosis in oncological pathologies, iconographic study of IBD, senology, endocrinology.

Dr. Nunzio Paolo Nuzzi has graduated at Università Cattolica del Sacro Cuore (Milan) and carried out his specialisation in neuroradiology. He is the Unit director of Interventional radiology at Humanitas Research Hospital.

Medical areas of interest: interventional neuroradiology, cerebrovascular diseases, ischemic and haemorrhagic stroke, brain aneurysms, brain and spinal arteriovenous malformations and arterial-venous fistulas (AVF), intracranial stenosis and neck stenosis.

Research areas of interest: new biomedical devices for the treatment of cerebrovascular diseases. Clinical research on minimally invasive endovascular procedures.

Dr. Giuseppe Marinari is a specialist in general surgery (1991) and nutrition (1995). He started his career in Bariatric Surgery in 1987 and, since then, he has performed over 7000 bariatric procedures, mainly Sleeve Gastrectomy, Gastric Bypass, and Biliopancreatic Diversion. Dr. Giuseppe Marinari has international experience, and he is one of the leading Bariatric surgeons in Italy. Over the past 10 years, he has focused on the implementation of a high-volume centre (>1250 procedures in 2019). Since 2016, he adopted an Enhanced Recovery After Bariatric Surgery (ERABS) protocol, to improve benefits for the patient. In essence, this means a faster recovery and an early return to daily activities, with a very high patient approval rating.

Obesity is a complex condition that encompasses a variety of comorbidities. Therefore, the role of a bariatric surgeon is multidisciplinary, including the understanding (and sometimes treating) of comorbidities as well as performing surgery.

Bariatrics interested Dr. Giuseppe Marinari at first because it was a new and growing field. He then developed an appreciation for the multidisciplinary aspect. Now Dr. Giuseppe Marinari is eager to help people transform their lives.

Dr. Giuseppe Marinari  was mentored by Prof. N. Scopinaro at the University Hospital in Genoa, Italy. He invented the biliopancreatic diversion (with or without duodenal switch), a malabsorptive bariatric operation. Dr. Marinari is now Director of the Bariatric Center. He has international experience and is one of the leading surgeons in his field. He performs both restrictive and malabsorbative bariatric procedures, mainly using the laparoscopic approach. In Humanitas Reasearch Hospital patients are treated by a multi-disciplinary team. The patients are given full attention and support throughout all the steps along the treatment.

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=marinari+giuseppe

Dr. Federico Pessina is the Cranial Neurosurgey Unit Director.

Medical areas of interest: Brain tumors, glioblastomas, low grade gliomas, brain metastases, meningiomas, neuromas, cavernous angiomas, brain aneurysms

Surgical treatment with brain mapping techniques, awake and minimally invasive surgery of all central nervous system tumors.

Surgical treatment of highly complex tumors of the skull base and cranio-cervical hinge: meningiomas, neuromas, craniopharyngiomas, brain stem tumors.

All the tumor pathologies described above are addressed after multidisciplinary multi-specialist evaluation.

The surgical approach is customized to the patient and to the type of lesion, making use of the most advanced intraoperative techniques for malignant brain tumors (neuronavigation, intraoperative neurophysiology, intraoperative CT) and more complex approaches (anterior, posterior and combined petroosectomies, minimally invasive accesses) for benign diseases of the skull base such as meningiomas and neuromas.

Research areas of interest: Experimental protocols in the treatment of glioblastomas

- Prospective protocols in the treatment of brain metastases

- Role of surgical removal and integrated treatments in glioblastomas and malignant brain tumors

- Intracranial meningiomas

- Cadaver lab dissection

Author of more than 60 scientific publications and 5 book chapters, he is member of Italian Society of Neurosurgery (SINCH).

In 2018 he joined the Scientific Committee of European Society of Neuroncology (EANO) and the Skull Base Surgery Committee of World Federation of Neurosurgical Society (WFNS).

Specialized training: 

Prof. Pessina obtained his Degree in Medicine and Surgery in University of  Insubria,  Varese, where he also completed his Residency Program.

From 2007 to 2008 he covered the role of Clinical Fellow in Neurosurgery in Lausanne University Hospital, focusing on image-guided intrinsic brain tumors resection and vascular neurosurgery

In 2018 he covered the Skull Base fellow position in Lariboisiere Hospital, Paris, fully dedicating to skull base surgery and hands-on dissection practice and teaching.

Since 2022, he is Full Professor in Neurosurgery (MED/27) in Humanitas University

Additional information of interest:

Member of the Scientific Committee of the European Association of Neuroncology (EANO)

Publications:  https://www.ncbi.nlm.nih.gov/pubmed/?term=Pessina+Federico

Dr. Daniela Pini is the Head of the Cardio-respiratory rehabilitation Unit.

Medical areas of interest: Dr. Daniela Pini has been working and researching heart failure and has gained considerable experience in the management of advanced forms of this pathology. She is also very interested in the evaluation and "overall" management of patients suffering from this disease, which mainly affects elderly people and who already have other chronic diseases, which, if neglected, can easily impair the effectiveness of treatment for heart failure itself.

Research areas of interest: new therapies for advanced heart failure: replacement therapy of the heart with mechanical assistance devices to the circulation or heart transplant. New drugs and devices. Multidisciplinary patient management programs.

Further information of interest: thanks to the high competence of cardiosurgeons, electrophysiologists and hemodynamists, Humanitas can count, as a clinical cardiologist, on a team that allows it to offer the patient all the range of therapeutic options for heart failure.

From June 2000 to October 2001 she was Visiting Assistant Professor at the Cardiovascular Division Hospital of the University of Pennsylvania. During this period, she worked in the Heart Failure/Heart Transplantation Program, where she participated in the management of patients with advanced heart failure waiting for transplantation, dealing in particular with medical complications in patients with mechanical assistance devices. She has also worked with kidney, kidney-pancreas, pancreas-insulae, lung, liver and heart transplant teams, dealing with the multiple aspects of managing solid organ transplant recipients.

She worked in the Niguarda Ca' Granda Hospital, at the Cardiomyopathy and Heart Transplantation Service, dealing mainly with patients with advanced heart failure and undergoing a cardiac transplant.

Dr. Pini is a member of the coordination committee of the Decompensation Area of the National Association of Medical Hospital Cardiologists – ANMCO. In the last two years she has been mainly concerned on building a network of “heart failure clinics” on the national territory.

Dr. Corrado Lodigiani has been assistant at the Thrombosis Centre of Humanitas research Hospital from 1998 to 2013 and he became Unit Director in 2013. 

Humanitas Thrombosis Center is a state-of-the-art service for the proper management of the diagnosis and therapy of venous thromboembolic pathology (deep and superficial venous thrombosis, pulmonary thromboembolism, visceral venous thrombosis) and arterial (myocardial infarction, cerebral stroke, peripheral arterial disease). 
Other also rare diseases treated are atypical thrombosis, such as the vascular circulation of the retina, the hearing system and the placental circulation during pregnancy. 

Dr. Lodigiani adopts the multidisciplinary approach and works in collaboration with all medical and surgical specialties. In particular, he carries out clinical and instrumental diagnostics (vascular ecocolordoppler) and research on the causes, diagnosis and therapy of thrombotic and bleeding disorders, congenital and acquired. His clinical activity also involves the diagnosis and management of patients suffering from bleeding diseases, such as haemophilia, von Willebrand’s disease and platelet diseases.

Medical areas of interest:  

In recent years, he has devoted himself with particular interest to the testing, in the role of Principal Investigator in International Clinical Studies, of new antithrombotic drugs and, above all, anticoagulants, which are about to be marketed and will constitute a valid and safe alternative to traditional oral anticoagulant therapy (DOACs). He is also working, with great interest, on researching the causes of idiopathic infertility and the usefulness and effectiveness of some therapeutic strategies, such as the use of anticoagulant drugs, improving the results of artificial insemination procedures. He is the author of numerous articles in international scientific journals and speaker at numerous national and international conferences.

Prof. Andrea Lania has graduated at the Università degli Studi of Milan and is specialized in endocrinology. He is the Unit Director of Endocrinology and Diabetology in Humanitas Research Hospital and his specialization is pituitary diseases, pituitary adenomas, thyroid cancer, pancreatic neuroendocrine tumors, poorly differentiated neuroendocrine carcinomas.

Medical areas of interest:
Pituitary tumors, hypopituitarism, acromegaly, Cushing’s disease and syndrome, neuroendocrine tumors, thyroid and thyroid diseases, adrenal and adrenal diseases, hypogonadism.

Research areas of interest:
Study of the pathogenetic mechanisms of pituitary and neuroendocrine tumors, of the molecular mechanisms responsible for the different response of pituitary and neuroendocrine tumors to medical therapy.

Prof. Lania published 198 peer-reviewed papers (Google Scholar H-Index 47; Scopus H-Index 38, cit tot 4604)

Prof. Lania has a long standing expertise in the field of intra-cellular signaling in endocrine tumors. In particular, in the past ten years, he contributed to analyze the role of PKA regulatory subunits in the pathogenesis and control of cell proliferation of endocrine tumors. Moreover, he contributed to define the role of SSTR5 domains involved in the intracellular trafficking of this receptor in human pituitary cells and to analyze the impact of DR2R and SSTR2&5 polymorphic variants on both the clinical outcome and response to medical treatment in patients with pituitary tumors.

Recently, he contributed to identify the role of cytoskeleton protein FLNA in mediating both intracellular signaling and membrane targeting of somatostatin type 2 receptor and D2R in pituitary and pancreatic neuroendocrine tumors. Finally, he contributed to explore the intracellular mechanisms possibly involved in mediating the interplay between drugs commonly used in the treatment of neuroendocrine tumors.

Previous experience:
2005-2008 Fondazione Ospedale Maggiore Policlinico IRCCS, Milan, Italy
Director of Endocrinologic Day Hospital and surgery on pituitary disorders. 

Publications: https://www.ncbi.nlm.nih.gov/pubmed?term=lania%20A 

Prof. Eduardo Nobile Orazio is the Neurology Unit Director in Humanitas Research Hospital. 

His main areas of interest and specialisation are: diagnosis and treatment of neuromuscular diseases, in particular polyneuropathies, also including those of immunological origin such as Guillain Barré Syndrome (GBS) and the different clinical variants, chronic inflammatory demyelinating polyneuropathy (CIDP), multifocal motor neuropathy (MMN), and the polyneuropathies associated with monoclonal gammopathy, the neuropathies and paraneoplastic neuronopathies and neuropathies in the course of haematologic diseases and from chemotherapy. 

Immunological diagnosis of autoimmune diseases of the peripheral and central nervous system, diagnosis and treatment of motor neurone disease with suspected paraneoplastic or immune genesis, diagnosis and treatment of Multiple Sclerosis and other autoimmune and inflammatory diseases of the central nervous system such as autoimmune and paraneoplastic encephalitis, diagnosis and treatment of Parkinson’s Disease and extrapyramidal diseases.

His areas of research are clinical and immunological diagnosis and treatment of the immune mediated polyneuropathies and, in particular, GBS, CIDP, MMN and polyneuropathy associated with monoclonal gammopathy including POEMS.

Prof. Eduardo Nobile Orazio has written over 230 scientific publications, held more than 85 university seminars or conferences. He has been a member of the SIN since 1991, of the European Neurological Society since 1989 until 2014, when he joined the European Academy of Neurology. Prof. Eduardo Nobile Orazio has also been a member of the American Academy of Neurology since 1998 and of the American Neurological Association since 2012.

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=Nobile-Or  

Prof. Nicola Portinaro is the Director of the Orthopaedic Paediatric and neuro-orthopaedic Unit at Humanitas Research Hospital, and is Professor of Orthopaedics and Traumatology at the University of Milan. 

He was appointed as Fellow of the Royal College of Surgeons, Edinburgh, and from 2000 until now, Honorary Special Senior Lecturer at University of Bristol, UK. Founder and Scientific Director of "Ariel Foundation", a non profit foundation for pediatric neurological disabilities founded in 2002. 

The team of Professor Portinaro is one of the internationally recognized leading teams in the field of paediatric orthopaedics and neuro-orthopaedic surgery with an experience of over 100 bone surgerical procedures on lower limb every year, including 50 pelvic osteotomies and more than 300 surgical procedures on muscles and tendons (lightening, transfer…). He is specialized in the treatment of lower and upper limb deformities related to Cerebral Palsy, Spina Brifida, Developmental Dysplasia of the Hip, Perthes Disease, clubfoot and alteration in skeletal development. 

A considerable part of his activity is in scientific research, with several experimental works with the goal of detecting uknown anchors aspects of diseases treated by him. His research fields include the study of genomic and proteomic of extracellular matrix proteins in different diseases. 

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=portinaro 

Prof. Marco Montorsi is the Director of the Department of General and digestive surgery unit in Humanitas Research Hospital and he is Professor of General Surgery at the Humanitas University. His academic career started in the the Humanitas University of Milan, where he entered in 1980 as Assistant Professor and was appointed as Professor of Surgery in 2001.

His main interests are in the field of digestive diseases and in the surgical treatment of the related pathologies, mainly hepatico-pancreatico-biliary (HPB) and colorectal pathologies. He is indeed the Director of the Department of Surgery in Humanitas Research Hospital where a great volume of major abdominal surgeries is routinely performed. Around 250 -300 hepatic and pancreatic resections and 350 colorectal resections.
He began performing laparoscopic colorectal surgery in the early 90s and gained a lot of experience in this field. The vast majority of colorectal tumours diagnosed in the department of Surgery is submitted to laparoscopic resection thus allowing a smooth and safe disease course. A robotic approach with the new Da Vinci equipment is now available for patients with rectal tumours.

Transanal endoscopic microsurgery (TEM) with dedicated instruments is also offered to selected patient with low-sited rectal tumours so sparing major abdominal approach.

A routine policy of strict interaction with the Dept. of Oncology is active for patients needing a perioperative chemo- and radiotherapy with the aim of full integration for a better care and results.

Prof. Marco Montorsi is also Humanitas University President with over 10 years of experience in didactic and clinic teaching to medical students.

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=montorsi+marco

Dr. Lucia Torracca is leading the Cardiac Surgery Unit at Humanitas Research Hospital. She received her training at Ospedali Civili di Brescia and at Ospedale San Raffaele with Professor Ottavio Alfieri, were she improved her knowledge in the mitral disease focusing in the reparative and preservative approaches. At the same institution she led the minimal invasive and robotic division before moving to Ospedali Riuniti Di Ancona to be chief of the Cardiac Surgery Complex Unit. Dr. Torracca has performed more than 55 hundred cardiac surgeries. Thanks to her surgical and academic curriculum, she has been an active member of the steering committee of the European Society editing Guidelines for the treatment of heart diseases.

Together with her team in Humanitas, she can approach every cardiac disease affecting adults, especially focusing on the minimal invasive approach to reparative valve disease. State of the art technologies are regularly explored and implemented in the Open Heart dedicated Operating Room and Intensive Care Unit to ensure best outcomes, shorter hospital stay and fewer surgical complications.

The surgical expertise of Dr. Torracca go from open heart circulatory-arrest procedure to off-pump and/or trans-catheter procedures (MitraClip or TransApical Aortic Valve Implants).

Dr. Torracca and her team can claim the highest rate of mitral valve repair in Bi-leaflet prolapse (Barlow Disease) hitting almost 99% of conservative approach in minimal invasiveness at the time of surgery, maintaining >95% success rate at long term follow up: this option is further advantageous in the youngest patient population allowing restrain from anticoagulation therapy and perfectly normal quality of life.

Author or co-author of 151 publications in national and international scientific journals.